Kevin Dudley Lab
We harness long-read sequencing to solve the transcript isoform annotation and quantification problem — understanding life through better genomes.
What we do
From transcriptome assembly to isoform quantification, our work spans the full long-read analysis pipeline.
Resolving the isoform annotation and quantification problem by incorporating long-read sequencing into gene annotation pipelines — recovering full-length transcripts in non-model organisms with fragmented reference genomes.
Applying Oxford Nanopore and PacBio long-read platforms to reveal new patterns of alternative splicing and refine the structural annotation of genomes.
Developing methods to accurately assign reads to the correct transcript in complex gene models, improving differential isoform expression analysis.
PCR-free, direct RNA nanopore sequencing to detect RNA modifications and isoforms without amplification bias.
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